一、个人简介

单世娟，女，中共党员，博士，副教授，硕士研究生导师。2017年6月毕业于山东师范大学动物学专业，2017年9月工作至今。承担细胞工程和免疫学等本科生课程教学，主持国家自然科学基金青年基金、中国博士后自然科学基金面上资助和山东省自然科学基金博士基金各1项，发表SCI论文14篇。

二、研究方向

鱼类天然免疫模式识别受体的鉴定及其抗病机理研究

三、承担项目

1.鱼类特有的TLR18调控鲤鱼抗菌肽表达的作用机制研究，32002419，国家自然科学基金青年项目，2021/01-2023/12，24万元，主持。

2．鱼类特异TLR18在鲤鱼抗细菌感染免疫中的作用机制研究，2017M622258，中国博士后科学基金面上资助，2017/11-2019/11，5万元，主持。

3．鱼类特异性模式识别受体TLR18的识别特性和作用机制研究，ZR2018BC054，山东省自然科学基金博士基金，2018/03-2020/12，8万元，主持。

4．黄鳝抗细菌病感染的免疫学基础, 2018YFD0900302，国家重点研发计划子课题，2018.12-2022.12，46万，参与。

5．鲤鱼新型免疫球蛋白IgT粘膜免疫特性及其抗体库多样性研究，31972828，国家自然科学基金面上项目，2020.1-2023.12，56万元，参与。

四、教学科研成果（论文、专著、专利等）

1.Shijuan Shan, Rongrong Liu, Hanxiao Feng, Yonghuan Zhang, Fumiao Zhang, Cui Lv, Guiwen Yang, Identification and functional characterization of the transcription factor NF-κB subunit p65 in common carp (Cyprinus carpio L.), Fish Shellfish Immunol, 2019, 95:25-34.

2.Shijuan Shan, rongrong Liu, Lei Jiang, Yaoyao Zhu, Hua Li, Weixian Xing, Guiwen Yang, Carp Toll-like receptor 8 (Tlr8): An intracellular Tlr that recruits TIRAP as adaptor and activates AP-1 pathway in immune response, Fish & Shellfish Immunology, 2018, 82:41-49

3.Shijuan Shan, Dezhi Liu, Rongrong Liu, Yaoyao Zhu, Ting Li, Fumiao Zhang, Liguo An, Guiwen Yang, Hua Li, Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp (Cyprinus carpio L.): Indications for a role of participation in the NF-κB signaling pathway, Fish & Shellfish Immunology, 2018, 72: 187-198.

4.Shijuan Shan, Chenchen Qi, Yaoyao Zhu, Hua Li,Liguo An*, Guiwen Yang*.Expression profile of carp IFN correlate with the up-regulation of interferon regulatory factor-1 (IRF-1)in vivo and in vitro: the pivotal molecules in antiviral defense, Fish & Shellfish Immunology, 2016, 52: 94-102.

4.Shijuan Shan#, Lei Wang#,Fumiao Zhang, Yaoyao Zhu, Liguo An* and Guiwen Yang*, Characterization and expression analysis of Toll-interacting protein in common carp, Cyprinus carpio L., responding to bacterial and viral challenge, Springerplus, 2016, 5:639.

6.Shijuan Shan, Dezhi Liu, Lei Wang, Yaoyao Zhu, Fumiao Zhang, Ting Li, Liguo An*and Guiwen Yang*, Identification and expression analysis of irak1 gene in common carp Cyprinus carpio L.: indications for a role of antibacterial and antiviral immunity. Journal of Fish Biology, 2015, 87: 241–255.

7. Fumiao Zhang#,Shijuan Shan#, Xiaoyang Xu, Yao Wang, Yonghuan Zhang, Miao Yin * and Guiwen Yang, Molecular characterization and expression analysis of two peptidoglycan recognition proteins (CcPGRP5, CcPGRP6) in larvae ontogeny of common carp Cyprinus carpio L. and upon immune stimulation by bacteria

8. Yaoyao Zhu#,Shijuan Shan#, Hanxiao Feng, Lei Jiang, Liguo An, Guiwen Yang, Hua Li, Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens. Journal of Fish Biology, 2019, 95:510–519

9. Yaoyao Zhu#,Shijuan Shan#, Huaping Zhao, Rongrong Liu, Hui Wang, Xinping Chen, Guiwen Yang and Hua Li, Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response. 2020, 16:450

10. Ting Li,Shijuan Shan, Lei Wang, Guiwen Yang, Jianping Zhu, Identification of a fish-specific NOD-like receptor subfamily C (NLRC) gene from common carp (Cyprinus carpio L.): Characterization, ontogeny and expression analysis in response to immune stimulation. 2018, 82:371–377

11. Yaoyao Zhu, Chenchen Qi,Shijuan Shan, FumiaoZhang, Hua Li, Liguo An*, GuiwenYang*, Characterization of common carp (Cyprinus carpio L.) interferon regulatory factor 5 (IRF5) and its expression in response to viral and bacterial challenges, BMC Veterinary Research, 2016, 12:127

12. Y. Y. Zhu, W. X. Xing,S. J. Shan, S. Q.Zhang, Y. Q. Li, T. Li, L. An*and G. W. Yang*, Characterization and immune response expression of the Rig-I-like receptor mda5 in common carp Cyprinus carpio, Journal of Fish Biology, 2016, 88: 2188-2202

13. Guiwen Yang, HongyanGuo, Hua Li,Shijuan Shan, Xueqing Zhang,Jan H.W.M. Rombout*, LiguoAn*. Molecular characterization of LEAP-2 cDNA in common carp(Cyprinus carpio L.) and the differential expression upon a Vibrio anguillarumstimulus; indications for a significant immune role in skin. Fish & Shellfish Immunology. 2014; 37(1): 22-29

14. Hua Li, Hongyan Guo,Shijuan Shan, Chenchen Qi, Liguo An* & GuiwenYang*. Characterization and expression pattern of a novel β-defensin in common carp (Cyprinus carpio L.): implications for its role inmucosal immunity. Bioscience, Biotechnology, and Biochemistry. 2014; 78 (3):430-437

五、获奖

山东省高等学校科学技术三等奖，2019年，第五位。